SAM-e Supplement Reviews, Dosage And How To Take

A number of resources provide guidelines with valuable recommendations on the right dosage of nootropics, but not for SAM-e.
You will not find any official recommendations on dosage for SAM-e since FDA (U.S. Food and Drug Administration) has not included this supplement in the approved list of medications and SAM-e has no official prescribed use.

But indication “not included in FDA list” does not necessarily mean something bad and in no case means that a drug is not safe or prohibited.

There is an opinion that such failure to get FDA approval is clearly could be explained by existent infeasibility to SAM-e’s patent because of it’s purely natural compounds in chemical structure.

And for that reason, neither pharmaceutical company would make any big profits from this natural supplement.
This supplement will always reside in a niche of natural supplements with a prescription defined from minor trials and practical considerations.

In this case, the only source to get a proper understanding of the right usage of SAM-e is online sources.

Previous studies published in Natural Medicines Database, recommendations of American Psychiatric Association and the Canadian Network for Mood and Anxiety Treatments and users’ reviews and recommendations summarized in this article.

It is worth to mention that all sources adhere to basic principles of SAM-e safe usage:

  • To define intended use;
  • Right dose to be determined with an  assistance of your therapist especially in case if you take other supplements, drugs or stacks;
  • Permanent monitoring of your body states for timely detecting any changes which could be probably related to side effects or overdosage;
  • Irregular and occasional usage of nootropics in order to avoid tolerance problems;
  • If any negative effects from nootropic showed up to immediately reduce your daily dosage and see your doctor.

And this approach becomes most important in cases where there is no available information on practical usage, side effects or due to either lack of clinical trials and studies or newness of the nootropic.

Any user before taking nootropics should have a general understanding and awareness of the following red flags which are the reason to see your doctor or to take other actions aimed to recover side effects of overdose:

  • are you started to experience side effects when increasing dose;
  • if you do not feel effect and benefits from taking nootropics in the dose which was sufficient enough earlier;

What is especially important when you self-administer a drug.

Depending on intended use, an average dose of SAM-e is required to deal with minor disorders like
smoking cessations (400-800 mg twice daily), liver disease (400-1200 mg daily), fibromyalgia (400 mg twice daily) and some neurological disorders – neurologic disorders  (maximum 800 mg daily) and schizophrenia (maximum 80 mg daily in divided doses).

But for other serious cases, the dose of SAM-e is required to be much higher: like depression (800-1600 mg daily), AHDH (maximum 2400 mg daily), cholestasis (1600 mg daily), osteoarthritis (600-1200 mg daily), sexual function disorders (maximum 1600 mg daily).

Since specified are considered as the large doses it should be taken very carefully since the large doses are known to cause mania or abnormally elevated mood.

A duration of taking SAM-e also depends on the dosage you take and severity of a disease.

Some disorders (neurologic disorders, anxiety, liver disease including liver cirrhosis, etc.) do not have guidelines for the duration of use since it is very individual and may take a long time to improve your condition hence it is recommended to take SAM-e under the care of your physician.

But for the following diseases it is normal to take SAM-e for 2 weeks for cholestasis and 4 weeks for AHDH; 6 weeks for depression, fibromyalgia and sexual function disorders; for schizophrenia it is about 7 weeks; 8 weeks is required to treat smoking cessations, and 12 weeks for osteoarthritis and a liver disease require 24 weeks of taking SAM-e.

The best way to take this nootropic is in several administrations starting from 200-400 mg by gradually increasing the dose and it is better to exclude taking SAM-e at night.
Users quite often provide reviews describing SAM-e performance stating that there is a great effect of this supplement while taking it for a depression, but in some cases, it was found to be less effective for anxiety.

SAM-E Reviews

From period 1984 to 2015 there were published a number of articles about results of trials, tests, and studies on SAM-e benefits where the test groups with different stages of diseases and deviations tried this supplement in an attempt to see the efficiency of SAM-e.

Since this supplement was discovered, several studies were conducted on the effects of SAM-e and recognized positive effects of this nootropic.

Users’ reviews about the benefits and side effects of this supplement gain significance due to the lack of researches and trials in this respect, except for the information from Natural Medicines Database.

Among available reviews about effects and benefits of SAM-e from sources (mostly online), each review is individual and devoted to a specific users’ problem.
And it is always interesting to compare an intended purpose of supplements which is initially always based on the researches and taken as basic, with a practical individual experience of users which does not always confirm studies’ results.

SAM-e is assumed to help with depression, neurologic disorders, AHDH, anxiety, liver disease, cholestasis, fibromyalgia, schizophrenia, sexual function disorders and others.
But in fact, SAM-e not always can be helpful for those who experience these diseases.
A majority of reviews say that SAM-e really helps with mood and related feeling of elation, energy, motivation, and mental activity.

SAM-e is used as an antidepressant and was recognized by users as a highly effective antidepressant releasing symptoms of depression on the seventh day from the begin date.
Users’ positive posts are supported by reports of American Psychiatric Association and Canadian Network for Mood and Anxiety Treatments which recommend SAM-e for depression disorders.
In some cases, SAM-e was considered to be even more effective than other similar range of antidepressants.

No response to SAM-e therapy for depression was mentioned in a few reviews and SAM-e produced some unpleasant effects typical for all nootropics like headaches, sleepiness, and gastrointestinal problems.

Statistics of Medical centers is a based on researches dedicated to SAM-e performance.
Many studies on efficiency of SAM-e as an anti-depressant were performed amongst women experienced postpartum depression (Obstetrics and Gynecology Clinics of North America, Journal of Neuropsychiatric Disease, Journal of Multidisciplinary Healthcare and many others)

Not so many researches were focused on SAM-e’s performance in treating anxiety, and this may probably be due to the fact that it is not only a symptom of a depression but also an independent disease, anxiety therapy, and SAM-e efficiency was proved within depression researches.

There are known several tests and patients’ reviews posted online of SAM-e for anxiety which testify that SAM-e could not be effective for anxiety if it is the only symptom but does successfully treat some symptoms of depression.

Minor positive reviews on Amazon.com in this respect will not radically change the whole picture (as some users successfully treated anxiety and stress by SAM-e).

Moreover, considering that in some instances users got anxiety as a side effect of SAM-e, if anxiety is the only symptom you are about to treat, you should be consulted with your therapist to not to worsen your symptoms.

Also, some studies showed SAM-e as an appropriate choice for ones who suffer from cognitive and nervous disorders and as a support therapy against cardiovascular and immune systems’ problems, also as an antioxidant, and against inflammation (by increasing homocysteine levels).

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